Associate Scientist, Downstream Process Development and Manufacturing (Contract)
Company: Dren Bio
Location: San Carlos
Posted on: February 11, 2026
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Job Description:
Associate Scientist, Downstream Process Development and
Manufacturing (Contract) About the Company: Dren Bio (the
"Company") is a privately held, clinical stage biopharmaceutical
company focused on developing therapeutic antibodies for the
treatment of cancer, autoimmune and other serious diseases. The
Company's management team and scientific advisors have profound
expertise covering the discovery and development of specially
engineered antibodies. Dren Bio's pipeline encompasses a multitude
of programs from its two distinct, wholly-owned technologies. The
Company's lead development candidate, DR-01, induces
antibody-mediated killing of a specific cell type known to play a
key role in various hematologic malignancies and autoimmune
disorders. In addition to DR-01, the Company has launched multiple
programs from its proprietary Targeted Myeloid Engager and
Phagocytosis Platform, a bispecific antibody-based technology that
offers a novel mechanism of action focused on selectively engaging
myeloid cells (antigen presenting cells) for the targeted depletion
of pathologic cells and other disease-causing agents. Function:
Purification Process Development and Manufacturing Level: Associate
Scientist (Contract) Location: San Carlos, CA Reporting Manager:
Director, Downstream Process Development About the Opportunity:
Dren Bio is seeking a highly motivated Associate Scientist to
become an integral member of the Downstream Process Development
group. The Downstream Process Development group is responsible for
critical drug development functions such as: development of robust
downstream processes, technology transfer and scale-up to contract
manufacturing facilities, and technical support and overseeing of
manufacturing at contract manufacturing facilities. The scope of
the position and requirements are described below. Role and
Responsibilities: Develop and scale-up robust multi-step
purification processes Timely documentation of experiments into lab
notebooks Present experimental data in project and group meetings
Author technical reports Implement new purification technologies to
optimize and streamline processes Transfer and oversee purification
process at CMO for GMP manufacturing Review executed batch records
from CMO manufacturing Produce material for in-house development
Education, Experience and Qualification Requirements: Bachelors or
Masters degree in Chemistry, Biochemistry or related scientific
field. 4 years of relevant industry experience for MS and 6 years
for BS level candidates. Required Skills and Experience:
Experienced in protein purification techniques including column
chromatography,standard membrane filtration and
Ultrafiltration/Diafiltration Working knowledge of AKTA systems and
Unicorn programming Ability to analyze and interpret complexed
process data Work independently and proactively with minimal
supervision Strong interpersonal skills and excellent oral and
written communication skills Ability to travel and perform
Person-in-Plant manufacturing oversight at a CMO ispreferred
Experience working with external manufacturing vendors and partners
is preferred Employment Practices: Dren Bio is an equal opportunity
employer. Employment decisions are based on merit and business
needs. Dren Bio will not discriminate against any job applicant
because of race, color, national origin, ancestry, gender, sexual
orientation, age, religion, creed, physical or mental disability,
gender identity, medical condition, pregnancy, marital status,
veteran status, or any other characteristic protected by federal,
state or local law.
Keywords: Dren Bio, Arden-Arcade , Associate Scientist, Downstream Process Development and Manufacturing (Contract), Science, Research & Development , San Carlos, California
